Document Detail

Ketosis with enhanced GABAergic tone promotes physiological changes in transcendental meditation.
MedLine Citation:
PMID:  10859661     Owner:  NLM     Status:  MEDLINE    
Transcendental meditation (TM) is a stylized form of physical and mental relaxation which is associated with changes in the secretion and release of several pituitary hormones. The hormonal changes induced by TM mimic the effects of the inhibitory neurotransmitter gamma aminobutyric acid (GABA). It is hypothesized that TM produces changes in pituitary hormone secretion by enhancing hypothalamic GABAergic tone as a result of TM associated ketosis. Ketosis enhances the entry of glutamate, the amino acid substrate of GABA into synaptosomes, making more glutamate available for conversion to GABA through the glutamate decarboxylase pathway.
A N Elias; S Guich; A F Wilson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  54     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-07-10     Completed Date:  2000-07-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  660-2     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Harcourt Publishers Ltd.
Department of Medicine, University of California at Irvine, California 92868, USA.
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MeSH Terms
Brain / metabolism
gamma-Aminobutyric Acid / metabolism*
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid

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