Document Detail


Ketosis-onset diabetes in Tunisian adults: immunological markers and beta-cell function.
MedLine Citation:
PMID:  20214161     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study in Tunisia was to classify ketosis-onset diabetes in adult patients. All patients aged > 30 years without known diabetes, presenting with ketosis and admitted to our department were studied. Patients with secondary or gestational diabetes and those on corticoid therapy or with coinciding infection were excluded. The data included clinical characteristics, immunological markers and beta-cell function. Of the 63 patients, islet-cell antibodies were present in 27.0%, glutamic acid decarboxylase antibodies in 25.4% and thyrosin phosphatase antibodies in 19.0%. Beta-cell functional reserve was preserved in 54.0%. Our results confirm that patients with ketosis-onset diabetes mellitus in adulthood are a heterogeneous group.
Authors:
F Harzallah; A Ben Brahim; L Laadhar; M Feki; M Zitouni; S Makni; N Kaabachi; H Slimane
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Eastern Mediterranean health journal = La revue de sant? de la M?diterran?e orientale = al-Majallah al-?i???yah li-sharq al-mutawassi?     Volume:  16     ISSN:  1020-3397     ISO Abbreviation:  East. Mediterr. Health J.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9608387     Medline TA:  East Mediterr Health J     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Diabetology, La Rabta Hospital, Tunis, Tunisia. fatma.harzallah@rns.tn
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Age of Onset
Analysis of Variance
Autoantibodies / immunology
Biological Markers* / blood
Chi-Square Distribution
Diabetes Mellitus, Type 1 / complications*
Diabetes Mellitus, Type 2 / complications*
Diabetic Ketoacidosis / blood,  epidemiology*,  etiology*
Female
Glutamate Decarboxylase / immunology
Humans
Insulin-Secreting Cells* / immunology
Male
Middle Aged
Statistics, Nonparametric
Tunisia / epidemiology
Urban Health / statistics & numerical data
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/islet cell antibody; EC 4.1.1.15/Glutamate Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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