| Ketorolac tromethamine use in a university-based emergency department. | |
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MedLine Citation:
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PMID: 7600400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the use of parenteral ketorolac tromethamine (KT) in the emergency department (ED). METHODS: During a six-month period, KT was administered in an uncontrolled, nonblinded fashion to a series of ED patients experiencing acute pain. The patients rated pain on a previously validated visual analog pain scale before receiving KT. They repeated this procedure one hour after KT administration, prior to additional analgesia, or preceding release, whichever came first. Analgesic response was assessed by comparing pretreatment and posttreatment pain scores for the entire study population by the Wilcoxon rank sum test. Possible effects of specific variables (patient age, gender, race, indication for KT, route, dose, previous use of NSAIDs, and concurrent administration of muscle relaxants) were assessed using the Kruskal-Wallis test. RESULTS: Of the 445 patients enrolled, 375 (84%) reported pain relief with KT, only seven (2%) worsened, and the remainder (14%) reported no change. Overall pain reduction was 37.6 +/- 27.2 (SD) mm (100-mm scale) for the entire study population. The pain scores obtained after KT administration were significantly lower than those obtained prior to KT administration (p < 0.001). The only variable that significantly influenced pain score reduction was indication for KT (p = 0.001). Nephrolithiasis and toothache patients had the largest mean reductions in pain. No significant side effect was reported. CONCLUSION: Parenteral KT is a useful and safe analgesic for ED patients. The agent generally provides analgesia and is particularly promising for patients with nephrolithiasis or toothache. |
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Authors:
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J M Bartfield; A M Kern; N Raccio-Robak; H S Snyder; R H Baevsky |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Volume: 1 ISSN: 1069-6563 ISO Abbreviation: Acad Emerg Med Publication Date: 1994 Nov-Dec |
Date Detail:
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Created Date: 1995-08-10 Completed Date: 1995-08-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9418450 Medline TA: Acad Emerg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 532-8 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine Albany Medical College, NY 12208 USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Analgesics / therapeutic use* Anti-Inflammatory Agents, Non-Steroidal / therapeutic use* Child Colic / drug therapy Confidence Intervals Drug Combinations Female Humans Ketorolac Tromethamine Kidney Calculi / drug therapy Male Middle Aged Pain / drug therapy* Pain Measurement Prospective Studies Tolmetin / analogs & derivatives*, therapeutic use Toothache / drug therapy Tromethamine / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Drug Combinations; 26171-23-3/Tolmetin; 74103-07-4/Ketorolac Tromethamine; 77-86-1/Tromethamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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