Document Detail

Ketorolac tromethamine LS 0.4% versus nepafenac 0.1% in patients having cataract surgery. Prospective randomized double-masked clinical trial.
MedLine Citation:
PMID:  17964399     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the clinical, subjective, and objective outcomes of the use of 2 topical nonsteroidal antiinflammatory drugs--ketorolac tromethamine LS 0.4% (Acular) and nepafenac 0.1% (Nevanac)--in patients having cataract surgery.
SETTING: Single-center private practice, Las Vegas, Nevada, USA.
METHODS: One hundred eighty-three patients (193 eyes) with visually significant cataract were recruited for the study. Consenting patients were randomized to a standard regimen of Acular, gatifloxacin 0.3% (Zymar), and prednisolone acetate 1% (Pred Forte) (ketorolac group) or Nevanac, moxifloxacin hydrochloride 0.5% (Vigamox), and prednisolone acetate (Econopred) (nepafenac group). Analysis included subjective complaints (burning, itching, foreign-body sensation, pain level after surgery) and objective findings (visual function, degree of inflammation in the anterior segment, complications).
RESULTS: The ketorolac group consisted of 94 patients (100 eyes) and the nepafenac group, 89 patients (93 eyes). The between-group differences in visual outcomes and anterior chamber inflammation were not statistically significant (mean P = .33). There was a higher incidence of posterior capsule opacification in the nepafenac group (P = 0.019). Patient satisfaction, patient compliance, and postoperative pain control were statistically significantly better in the ketorolac group (P = .022, P = .023, and P = .025, respectively).
CONCLUSION: Ketorolac tromethamine was statistically significantly better than nepafenac in terms of patient satisfaction, compliance, and postoperative pain control.
Hon-Vu Q Duong; Kenneth C Westfield; Thomas H F Chalkley
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  33     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-29     Completed Date:  2007-12-20     Revised Date:  2013-08-26    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1925-9     Citation Subset:  IM    
Nevada State College, Henderson, Nevada 89012, USA.
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MeSH Terms
Administration, Topical
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*,  adverse effects
Benzeneacetamides / administration & dosage*,  adverse effects
Double-Blind Method
Ketorolac Tromethamine / administration & dosage*,  adverse effects
Lens Capsule, Crystalline / drug effects
Lens Implantation, Intraocular*
Middle Aged
Ophthalmic Solutions / administration & dosage,  adverse effects
Pain, Postoperative / prevention & control*
Patient Compliance
Patient Satisfaction
Phenylacetates / administration & dosage*,  adverse effects
Prospective Studies
Uveitis, Anterior / prevention & control*
Visual Acuity / drug effects
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Benzeneacetamides; 0/Ophthalmic Solutions; 0/Phenylacetates; 0J9L7J6V8C/nepafenac; 74103-07-4/Ketorolac Tromethamine
Comment In:
J Cataract Refract Surg. 2008 Mar;34(3):345-6; author reply 346   [PMID:  18299048 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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