Document Detail

Ketorolac in thyroid surgery: quantifying the risk of hematoma.
MedLine Citation:
PMID:  21518639     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Hematoma is a potentially life-threatening complication of thyroid surgery. Ketorolac is a nonsteroidal anti-inflammatory drug with known antiplatelet activity that is used for analgesia. The goal of this study was to determine the risk of hematoma in patients who received ketorolac in thyroid surgery.
DESIGN: Retrospective cohort study.
SETTING: London Health Sciences Centre.
METHODS: A retrospective cohort study was conducted of patients who underwent thyroid surgery between 2002 and 2007. Data were analyzed using the Fisher exact test.
MAIN OUTCOME MEASURES: Incidence of postoperative hematoma and perioperative ketorolac administration.
RESULTS: Thirteen hematomas occurred in 799 patients. Of the 799, 183 patients received ketorolac (22.9%) and 616 did not. Five in the ketorolac group (2.73%) and eight in the nonketorolac group (1.30%) developed hematomas. The calculated relative risk was 2.10 (95% CI 0.70-6.35).
CONCLUSIONS: Although there was an increased incidence of hematomas in the group receiving ketorolac, the difference was not statistically significant. The lack of significance may be due to the low number of hematomas.
Christopher J Chin; Jason H Franklin; Benjamin Turner; Leigh Sowerby; Kevin Fung; John H Yoo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale     Volume:  40     ISSN:  1916-0216     ISO Abbreviation:  J Otolaryngol Head Neck Surg     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-04-26     Completed Date:  2011-08-11     Revised Date:  2013-04-10    
Medline Journal Info:
Nlm Unique ID:  101479544     Medline TA:  J Otolaryngol Head Neck Surg     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  196-9     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, London Health Sciences Centre, University of Western Ontario, London, ON.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Hematoma / chemically induced*
Ketorolac / adverse effects*
Middle Aged
Thyroid Gland / surgery*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 66635-83-4/Ketorolac

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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