Document Detail

Ketone body utilization in duodenum. Differential effect of fasting on lipogenesis from acetoacetate and 3-hydroxybutyrate.
MedLine Citation:
PMID:  2575906     Owner:  NLM     Status:  MEDLINE    
The effect of fasting and refeeding on oxidation, lipogenesis and amino acid synthesis from ketone bodies has been studied in neonatal chick duodenal mucosa. Oxidation and amino acid synthesis were higher from acetoacetate and were stimulated by fasting from both 3-hydroxybutyrate and acetoacetate. On the contrary, lipogenesis was always higher from 3-hydroxybutyrate and fasting reduced lipogenesis rate from acetoacetate (by 66%) but not from 3-hydroxybutyrate. Results suggests the existence of a cytosolic fast-dependent acetoacetyl-CoA synthetase in chick duodenal mucosa which is involved in phospholipid synthesis.
G J Caamaño; M A Sánchez-del-Castillo; J Iglesias; E García-Peregrín; A Linares
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemistry international     Volume:  19     ISSN:  0158-5231     ISO Abbreviation:  Biochem. Int.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-03-08     Completed Date:  1990-03-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8100311     Medline TA:  Biochem Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  855-61     Citation Subset:  IM    
Departamento de Bioquímica y Biología Molecular, Universidad de Granada, Spain.
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MeSH Terms
3-Hydroxybutyric Acid
Acetate-CoA Ligase
Acetoacetates / blood,  pharmacology*
Amino Acids / biosynthesis
Cytosol / enzymology
Duodenum / metabolism*
Hydroxybutyrates / blood,  pharmacology*
Ketone Bodies / metabolism*
Lipids / biosynthesis*
Reg. No./Substance:
0/Acetoacetates; 0/Amino Acids; 0/Hydroxybutyrates; 0/Ketone Bodies; 0/Lipids; 300-85-6/3-Hydroxybutyric Acid; EC Ligase

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