| Ketone body utilization in duodenum. Differential effect of fasting on lipogenesis from acetoacetate and 3-hydroxybutyrate. | |
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MedLine Citation:
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PMID: 2575906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of fasting and refeeding on oxidation, lipogenesis and amino acid synthesis from ketone bodies has been studied in neonatal chick duodenal mucosa. Oxidation and amino acid synthesis were higher from acetoacetate and were stimulated by fasting from both 3-hydroxybutyrate and acetoacetate. On the contrary, lipogenesis was always higher from 3-hydroxybutyrate and fasting reduced lipogenesis rate from acetoacetate (by 66%) but not from 3-hydroxybutyrate. Results suggests the existence of a cytosolic fast-dependent acetoacetyl-CoA synthetase in chick duodenal mucosa which is involved in phospholipid synthesis. |
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Authors:
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G J Caamaño; M A Sánchez-del-Castillo; J Iglesias; E García-Peregrín; A Linares |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemistry international Volume: 19 ISSN: 0158-5231 ISO Abbreviation: Biochem. Int. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1990-03-08 Completed Date: 1990-03-08 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100311 Medline TA: Biochem Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 855-61 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica y Biología Molecular, Universidad de Granada, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxybutyric Acid Acetate-CoA Ligase Acetoacetates / blood, pharmacology* Amino Acids / biosynthesis Animals Chickens Cytosol / enzymology Duodenum / metabolism* Fasting* Hydroxybutyrates / blood, pharmacology* Ketone Bodies / metabolism* Lipids / biosynthesis* Male |
| Chemical | |
Reg. No./Substance:
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0/Acetoacetates; 0/Amino Acids; 0/Hydroxybutyrates; 0/Ketone Bodies; 0/Lipids; 300-85-6/3-Hydroxybutyric Acid; EC 6.2.1.1/Acetate-CoA Ligase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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