Document Detail


Ketone body turnover at term and in premature newborns in the first 2 weeks after birth.
MedLine Citation:
PMID:  7766735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using the infusion of D-(-)-3-hydroxy-[1,2,3,4,-13C4]butyrate at tracer doses, we measured total ketone body turnover in 13 premature and 10 at term infants in the first 2 weeks after birth. The premature infants received parenteral and/or oral feeding. The normal newborns were either recently fed or briefly fasting. The premature and the fed at term infants had comparable concentrations of ketone body (476 +/- 86 and 406 +/- 78 mumol/l) and free fatty acids (FFA) (309 +/- 47 and 325 +/- 75 mumol/l). In the premature newborns, ketone body turnover rates (3.2 +/- 0.2 mumol kg-1 min-1) were 74% that of fed newborns at term (4.3 +/- 0.3 mumol kg-1 min-1, p < 0.05), and 18% that of normal newborns during a brief fast (17.3 +/- 1.3 mumol kg-1 min-1, p < 0.01). Ketone body production rates correlated with plasma FFA concentrations in both groups (r = 0.62 and 0.69, p < 0.05). However, for a similar plasma FFA content, ketone production was 2- to 3-fold lower in the premature, indicating an immature hepatic capacity to convert FFA into ketones. Our study therefore shows that ketogenesis is already active in infants born 10 weeks before normal term and continuously fed, but that daily ketone production is lower than at term.
Authors:
D de Boissieu; F Rocchiccioli; N Kalach; P F Bougnères
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  67     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1995  
Date Detail:
Created Date:  1995-07-05     Completed Date:  1995-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  84-93     Citation Subset:  IM    
Affiliation:
INSERM U342, Hôpital Saint-Vincent-de-Paul, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Fasting
Fatty Acids, Nonesterified / blood
Female
Humans
Infant, Newborn / blood,  metabolism*
Infant, Premature / blood,  metabolism*
Insulin / blood
Ketone Bodies / biosynthesis*,  blood
Male
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Ketone Bodies; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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