| Ketone Bodies in Epilepsy. | |
| | |
MedLine Citation:
|
PMID: 22268909 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Seizures that are resistant to standard medications remain a major clinical problem. One underutilized option for patients with medication-resistant seizures is the high-fat, low-carbohydrate ketogenic diet. The diet received its name based on the observation that patients consuming this diet produce ketone bodies (e.g., acetoacetate, β-hydroxybutyrate, and acetone). Although the exact mechanisms of the diet are unknown, ketone bodies have been hypothesized to contribute to the anticonvulsant and antiepileptic effects. In this review, anticonvulsant properties of ketone bodies and the ketogenic diet are discussed (including GABAergic and glutamatergic effects). Because of the importance of ketone body metabolism in the early stages of life, the effects of ketone bodies on developing neurons in vitro also are discussed. Understanding how ketone bodies exert their effects will help optimize their use in treating epilepsy and other neurological disorders. © 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry. |
| | |
Authors:
|
Melanie A McNally; Adam L Hartman |
Related Documents
:
|
22129799 - The relationship between quality of life and coping strategies of adults with celiac di... 22082499 - Sarcopenic obesity: strategies for management. 12923329 - Pirfenidone suppressed the development of glomerulosclerosis in the fgs/kist mouse. 11701189 - Short-term exposure to dietary pb and/or dmsa affects dopamine and dopamine metabolite ... 11099649 - Chronic toxicity of di(2-ethylhexyl)phthalate in mice. 6140089 - The natural history and dose-response characteristics of enzyme-altered foci in rat liv... 1731859 - Influx in vivo of low density, intermediate density, and very low density lipoproteins ... 21282049 - Abresham ameliorates dyslipidemia, hepatic steatosis and hypertension in high-fat diet ... 22521039 - Metabolic dysfunction in late-puberty adolescent girls with type 1 diabetes: relationsh... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-23 |
Journal Detail:
|
Title: Journal of neurochemistry Volume: - ISSN: 1471-4159 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Authors. Journal of Neurochemistry © 2012 International Society for Neurochemistry. |
Affiliation:
|
Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Shaping Single-Walled Metal Oxide Nanotubes from Precursors of Controlled Curvature.
Next Document: Feature migration in time: Reflection of selective attention on speech errors.