Document Detail

Ketogenic diets: evidence for short- and long-term efficacy.
MedLine Citation:
PMID:  19332337     Owner:  NLM     Status:  MEDLINE    
The use of dietary treatments for epilepsy (ketogenic, modified Atkins, and low glycemic index diets) has been in continuous use since 1921. These treatments have been well studied in the short term, with approximately half of children having at least a 50% reduction in seizures after 6 months. Approximately one third will attain >90% reduction in their seizures. Animal studies confirm these findings, with broad evidence demonstrating acute anticonvulsant effects of the diet. Furthermore, the diet appears to maintain its efficacy in humans when provided continuously for several years. Interestingly, benefits may be seen long term even when the diet is discontinued after only a few months of use, suggesting neuroprotective effects. This potential antiepileptogenic activity has been recently demonstrated in some animal studies as well. This review discusses the animal and human evidence for both short- and long-term benefits of dietary therapies.
Eric H Kossoff; Jong M Rho
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics     Volume:  6     ISSN:  1933-7213     ISO Abbreviation:  Neurotherapeutics     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-31     Completed Date:  2009-06-05     Revised Date:  2014-08-31    
Medline Journal Info:
Nlm Unique ID:  101290381     Medline TA:  Neurotherapeutics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  406-14     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Epilepsy / diet therapy*
Ketogenic Diet*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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