| Ketogenic diet in the treatment of seizures associated with hypothalamic hamartomas. | |
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MedLine Citation:
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PMID: 21377333 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Seizures associated with hypothalamic hamartoma (HH) are notoriously intractable to medical therapy, and while surgical resection affords most affected patients with complete or near seizure-freedom, there remains a need to identify alternative treatments. In this retrospective study, we identified six patients from a large cohort of 220 patients with HH who were treated with the ketogenic diet (KD). Four patients had a 50-90% reduction in multiple seizure types (including gelastic, partial-onset and atonic seizures), and two individuals failed to respond. In order to study possible mechanisms, we then performed microelectrode recordings of small neurons in surgically resected HH tissue slices. Exposure to ketone bodies decreased spontaneous firing in 5 of 7 small HH neurons. These preliminary results suggest that seizures associated with HH may respond favorably to the KD, and that ketone bodies might directly modulate the intrinsic epileptogenicity of HH tissue. |
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Authors:
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Kevin E Chapman; Do-Young Kim; Jong M Rho; Yu-Tze Ng; John F Kerrigan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-3 |
Journal Detail:
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Title: Epilepsy research Volume: - ISSN: 1872-6844 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Barrow Neurological Institute and St. Joseph's Hospital & Medical Center, Phoenix, AZ 85013, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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