Document Detail


Ketogenesis from lactate in rat liver during the perinatal period.
MedLine Citation:
PMID:  1570209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lactate, which accumulates in neonatal plasma during the first hours after delivery, is used by neonatal tissues as a source of energy and carbon skeleton. In this work, lactate use by rat liver during late gestation (last 3 d) and early neonatal life (6 h postpartum) has been studied. The rate of lactate use by liver was compared with that found with oleate, inasmuch as fatty acids are the main substrates for the liver after the onset of lactation. The main fate of lactate in the liver during the perinatal period was ketone bodies, preferentially over CO2 and lipids. The rate of oxidation of lactate and its incorporation into lipids decreased during late gestation, but the rate of ketogenesis from lactate remained high during this period. After birth, the rate of lactate oxidation sharply increased, but lipogenesis decreased and ketogenesis was maintained. The rates of oleate oxidation and ketogenesis from oleate were two orders of magnitude lower than those from lactate. However, the rate of oleate incorporation into lipids was only 4-fold lower than that observed from lactate under the same circumstances. Our results suggest that lactate is a major substrate for the liver during the perinatal period because it is mainly incorporated into ketone bodies. This may target lactate carbons to different neonatal tissues.
Authors:
A Almeida; J P Bolaños; J M Medina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  31     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-05-27     Completed Date:  1992-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-8     Citation Subset:  IM    
Affiliation:
Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Salamanca, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Female
Ketone Bodies / biosynthesis*
Kinetics
Lactates / metabolism*
Lactic Acid
Lipids / biosynthesis
Liver / metabolism*
Oleic Acid
Oleic Acids / metabolism
Oxidation-Reduction
Pregnancy
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Ketone Bodies; 0/Lactates; 0/Lipids; 0/Oleic Acids; 112-80-1/Oleic Acid; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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