Document Detail

Ketoconazole treatment of Candida esophagitis--a prospective study of 12 cases.
MedLine Citation:
PMID:  6303114     Owner:  NLM     Status:  MEDLINE    
Candida infection of the esophagus is a frequent occurrence in both symptomatic and asymptomatic patients. In the present study, 12 symptomatic consecutive patients with Candida esophagitis. were successfully treated with oral Ketoconazole in a single dose of 200 mg daily. Response to treatment occurred in 8 days or less, with complete resolution of symptoms and endoscopic clearing of lesions. We found Ketoconazole to be well tolerated except for one patient who developed nausea, vomiting, and facial flushing while on the drug, which seemed to have been precipitated by alcohol intake. No changes in liver function tests were noted. Ketoconazole in this study was universally effective. In addition, its ease of administration, cost effectiveness, and low toxicity make it, in our opinion, the initial therapy of choice for C. esophagitis.
R A Fazio; P C Wickremesinghe; E L Arsura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  78     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-4     Citation Subset:  IM    
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MeSH Terms
Candidiasis / diagnosis,  drug therapy*
Esophagitis / diagnosis,  drug therapy*
Imidazoles / administration & dosage*,  therapeutic use
Middle Aged
Piperazines / administration & dosage*,  therapeutic use
Prospective Studies
Reg. No./Substance:
0/Imidazoles; 0/Piperazines; 65277-42-1/Ketoconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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