| Ketoconazole treatment of Candida esophagitis--a prospective study of 12 cases. | |
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MedLine Citation:
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PMID: 6303114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Candida infection of the esophagus is a frequent occurrence in both symptomatic and asymptomatic patients. In the present study, 12 symptomatic consecutive patients with Candida esophagitis. were successfully treated with oral Ketoconazole in a single dose of 200 mg daily. Response to treatment occurred in 8 days or less, with complete resolution of symptoms and endoscopic clearing of lesions. We found Ketoconazole to be well tolerated except for one patient who developed nausea, vomiting, and facial flushing while on the drug, which seemed to have been precipitated by alcohol intake. No changes in liver function tests were noted. Ketoconazole in this study was universally effective. In addition, its ease of administration, cost effectiveness, and low toxicity make it, in our opinion, the initial therapy of choice for C. esophagitis. |
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Authors:
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R A Fazio; P C Wickremesinghe; E L Arsura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 78 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1983 May |
Date Detail:
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Created Date: 1983-06-10 Completed Date: 1983-06-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 261-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Candidiasis / diagnosis, drug therapy* Endoscopy Esophagitis / diagnosis, drug therapy* Female Humans Imidazoles / administration & dosage*, therapeutic use Ketoconazole Male Middle Aged Piperazines / administration & dosage*, therapeutic use Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 0/Piperazines; 65277-42-1/Ketoconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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