| Ketoconazole, leukotrienes, Paf-acether and nicotine as a hapten: the possible aetiology of seborrhoeic dermatitis. | |
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MedLine Citation:
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PMID: 2886895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is evidence in some individuals that seborrhoeic dermatitis is an immuno-allergic reaction induced by nicotine as hapten. Nicotine is present in passive smoking, botanic areas, some foods at very low levels, smokeless tobacco and chewing gums. The successful use of topical ketoconazole as an anti-fungal treatment has been recently explained by its anti-leukotrienes properties in vitro, in vivo and by its capacity to inhibit the leukotrienes-mediated anaphylactic bronchoconstriction in the guinea-pigs. The occurrence of hypersensitivity to nicotine in seborrhoeic dermatitis remains to be determined, but an other original view is open for a better comprehension of an old disease. |
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Authors:
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B J Sudan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 23 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-09-24 Completed Date: 1987-09-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 33-8 Citation Subset: IM; X |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications Antipsychotic Agents / adverse effects Dermatitis, Seborrheic / drug therapy, etiology* Haptens / immunology Humans Ketoconazole / therapeutic use Leukotriene B4 / immunology Malassezia / isolation & purification Models, Biological Nicotine / immunology* Platelet Activating Factor / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Haptens; 0/Platelet Activating Factor; 54-11-5/Nicotine; 65277-42-1/Ketoconazole; 71160-24-2/Leukotriene B4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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