Document Detail

Ketoconazole, leukotrienes, Paf-acether and nicotine as a hapten: the possible aetiology of seborrhoeic dermatitis.
MedLine Citation:
PMID:  2886895     Owner:  NLM     Status:  MEDLINE    
There is evidence in some individuals that seborrhoeic dermatitis is an immuno-allergic reaction induced by nicotine as hapten. Nicotine is present in passive smoking, botanic areas, some foods at very low levels, smokeless tobacco and chewing gums. The successful use of topical ketoconazole as an anti-fungal treatment has been recently explained by its anti-leukotrienes properties in vitro, in vivo and by its capacity to inhibit the leukotrienes-mediated anaphylactic bronchoconstriction in the guinea-pigs. The occurrence of hypersensitivity to nicotine in seborrhoeic dermatitis remains to be determined, but an other original view is open for a better comprehension of an old disease.
B J Sudan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  23     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-09-24     Completed Date:  1987-09-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  IM; X    
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications
Antipsychotic Agents / adverse effects
Dermatitis, Seborrheic / drug therapy,  etiology*
Haptens / immunology
Ketoconazole / therapeutic use
Leukotriene B4 / immunology
Malassezia / isolation & purification
Models, Biological
Nicotine / immunology*
Platelet Activating Factor / immunology
Reg. No./Substance:
0/Antipsychotic Agents; 0/Haptens; 0/Platelet Activating Factor; 54-11-5/Nicotine; 65277-42-1/Ketoconazole; 71160-24-2/Leukotriene B4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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