| Ketoconazole in the treatment of blepharitis. | |
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MedLine Citation:
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PMID: 2138985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double masked, placebo controlled clinical trial, of topical 2% ketoconazole cream with lid hygiene, for the treatment of seborrhoeic and mixed seborrhoeic/staphylococcal blepharitis was conducted. Forty patients with symptomatic blepharitis, 20 randomly allocated to ketoconazole, 20 to placebo were entered. Treatment efficacy was assessed by improvement of symptoms using visual analogue scales, appearance of the eyelids and reduction in numbers of pityrosporum yeasts on the eyelids. Both groups showed a similar reduction in symptoms, and signs of inflammation. The overall clinical impression in the ketoconazole group was better at week five than in the placebo group. Sixty nine per cent were either normal or markedly improved, as compared to 42% in the placebo group, although this was not statistically significant (p less than 0.1, one-sided Mann-Whitney). Pityrosporum numbers were reduced significantly in both groups during the treatment period. Ketoconazole was no better than placebo at improving the symptoms of blepharitis. More ketoconazole treated patients had normal or markedly improved lids after treatment than the placebo group. Pityrosporum yeasts may play a role in blepharitis, and treatment with an antifungal has some advantages over conventional therapy. |
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Authors:
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M E Nelson; G Midgley; N R Blatchford |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Eye (London, England) Volume: 4 ( Pt 1) ISSN: 0950-222X ISO Abbreviation: Eye (Lond) Publication Date: 1990 |
Date Detail:
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Created Date: 1990-05-16 Completed Date: 1990-05-16 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8703986 Medline TA: Eye (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 151-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Blepharitis / drug therapy*, microbiology Dermatitis, Seborrheic / drug therapy Double-Blind Method Eyelid Diseases / drug therapy* Female Humans Hygiene Ketoconazole / therapeutic use* Malassezia / isolation & purification Male Middle Aged Randomized Controlled Trials as Topic Staphylococcal Infections / drug therapy |
| Chemical | |
Reg. No./Substance:
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65277-42-1/Ketoconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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