Document Detail


Ketoconazole in the prevention of acute respiratory distress syndrome.
MedLine Citation:
PMID:  9620108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We conducted a critical review of the literature on ketoconazole in preventing acute respiratory distress syndrome (ARDS), a serious disorder associated with high mortality. Two double-blind, prospective, placebo-controlled, randomized trials compared ketoconazole with placebo for prophylaxis of ARDS. In one trial, compared with placebo, ketoconazole resulted in a reduced frequency of ARDS (6% vs 31%, p<0.01), lower plasma thromboxane B2 levels (33 vs 75 pg/ml, p<0.05), and shorter intensive care unit stay (7 vs 15.5 days, p<0.05). In the second trial the drug reduced the frequency of ARDS (15% vs 64%, p=0.002), lowered thromboxane B2 levels (83 vs 143 pg/ml), and reduced mortality (15% vs 39%, p=0.05) compared with placebo. Larger multicenter studies are warranted to validate the findings of these two trials.
Authors:
A DeVries; W M Semchuk; J G Betcher
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  18     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-07-13     Completed Date:  1998-07-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  581-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, Plains Health Centre, Regina, Saskatchewan, Canada.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / therapeutic use*
Humans
Ketoconazole / therapeutic use*
Randomized Controlled Trials as Topic
Respiratory Distress Syndrome, Adult / blood,  mortality,  physiopathology,  prevention & control*
Thromboxane B2 / antagonists & inhibitors*,  blood
Chemical
Reg. No./Substance:
0/Antifungal Agents; 54397-85-2/Thromboxane B2; 65277-42-1/Ketoconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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