| Ketanserin, hypertension, and chronic alcoholism: double-blind study in forty patients. | |
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MedLine Citation:
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PMID: 3068159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a randomized double-blind trial involving 40 alcoholic hypertensive patients, the antihypertensive activity of ketanserin, a serotonin antagonist with high affinity for S2 serotonergic receptors, was compared with a placebo. Patients in both groups were matched for age, body weight, blood pressure, alcoholic consumption, and length of alcoholism. The administration of ketanserin significantly reduced (p less than 0.001) mean supine blood pressure from 167/106 mmHg (22.3/14.1 kPa) at baseline to 145/87 mmHg (19.3/11.6 kPa) after 90 days of treatment versus a slight non-significant reduction with the placebo. No significant changes in heart rate, body weight, or laboratory parameters occurred. The incidence of side-effects was low in both groups. The results of this study suggest the possible role of serotonin in the pathogenesis of alcohol-related hypertension and the potential treatment of the disease using S2-receptor antagonists such as ketanserin. |
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Authors:
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A de Lorenzo; M Ceccanti; G Assogna; M Romeo; G Cavaleri; M L Attilia |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of clinical pharmacology research Volume: 8 ISSN: 0251-1649 ISO Abbreviation: Int J Clin Pharmacol Res Publication Date: 1988 |
Date Detail:
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Created Date: 1989-04-19 Completed Date: 1989-04-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110183 Medline TA: Int J Clin Pharmacol Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 321-5 Citation Subset: IM |
Affiliation:
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National Council of Research, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alcoholism / drug therapy* Blood Pressure / drug effects Clinical Trials as Topic Double-Blind Method Female Humans Hypertension / drug therapy*, physiopathology Ketanserin / administration & dosage, adverse effects, therapeutic use* Male Middle Aged Random Allocation |
| Chemical | |
Reg. No./Substance:
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74050-98-9/Ketanserin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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