Document Detail

Ketanserin, hypertension, and chronic alcoholism: double-blind study in forty patients.
MedLine Citation:
PMID:  3068159     Owner:  NLM     Status:  MEDLINE    
In a randomized double-blind trial involving 40 alcoholic hypertensive patients, the antihypertensive activity of ketanserin, a serotonin antagonist with high affinity for S2 serotonergic receptors, was compared with a placebo. Patients in both groups were matched for age, body weight, blood pressure, alcoholic consumption, and length of alcoholism. The administration of ketanserin significantly reduced (p less than 0.001) mean supine blood pressure from 167/106 mmHg (22.3/14.1 kPa) at baseline to 145/87 mmHg (19.3/11.6 kPa) after 90 days of treatment versus a slight non-significant reduction with the placebo. No significant changes in heart rate, body weight, or laboratory parameters occurred. The incidence of side-effects was low in both groups. The results of this study suggest the possible role of serotonin in the pathogenesis of alcohol-related hypertension and the potential treatment of the disease using S2-receptor antagonists such as ketanserin.
A de Lorenzo; M Ceccanti; G Assogna; M Romeo; G Cavaleri; M L Attilia
Related Documents :
10333849 - Lifestyle modifications to prevent and control hypertension. 3. recommendations on alco...
935849 - Calcium content of river water, trace element concentrations in toenails, and blood pre...
24678939 - A controlled trial of renal denervation for resistant hypertension.
3327929 - Diet and hypertension: critical concepts and controversies.
11911719 - Coffee intake and risk of hypertension: the johns hopkins precursors study.
10202399 - Antioxidant capacity and polyphenolic components of teas: implications for altering in ...
6597819 - Blood pressure and blood group markers: association with the mn locus.
2761929 - Cardiac output measurements during and after triplet gestation.
11226079 - The influence of intravascular volume therapy with a new hydroxyethyl starch preparatio...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of clinical pharmacology research     Volume:  8     ISSN:  0251-1649     ISO Abbreviation:  Int J Clin Pharmacol Res     Publication Date:  1988  
Date Detail:
Created Date:  1989-04-19     Completed Date:  1989-04-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8110183     Medline TA:  Int J Clin Pharmacol Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  321-5     Citation Subset:  IM    
National Council of Research, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alcoholism / drug therapy*
Blood Pressure / drug effects
Clinical Trials as Topic
Double-Blind Method
Hypertension / drug therapy*,  physiopathology
Ketanserin / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Random Allocation
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Left atrial myxoma infected with Streptococcus viridans.
Next Document:  Effects of a synthetic prostanoid, rosaprostol, on the changes of gastric acidity and digestive diso...