Document Detail

Ketanserin does not prevent ACTH-induced hypertension in sheep.
MedLine Citation:
PMID:  2988838     Owner:  NLM     Status:  MEDLINE    
The role of serotonin (5HT) in the pathogenesis of ACTH-induced hypertension in sheep has been examined. The pressor responses to injections of 5HT (0.1-30 micrograms/kg) were similar in normotensive and hypertensive sheep. Prior treatment with the 5HT2 receptor antagonist ketanserin had no effect on the development of hypertension produced by ACTH administration.
M A Nelson; J P Coghlan; D A Denton; J A Whitworth; B A Scoggins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  12     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1985 Mar-Apr
Date Detail:
Created Date:  1985-08-01     Completed Date:  1985-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / antagonists & inhibitors*
Blood Pressure / drug effects*
Hypertension / physiopathology*,  prevention & control
Piperidines / pharmacology*
Serotonin / physiology
Serotonin Antagonists / pharmacology*
Reg. No./Substance:
0/Piperidines; 0/Serotonin Antagonists; 50-67-9/Serotonin; 74050-98-9/Ketanserin; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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