Document Detail

Ketamine in the management of generalised cephalic tetanus.
MedLine Citation:
PMID:  18036282     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Tetanus is a fatal infection caused by the neurotoxin tetanospasmin released by the vegetative spores of Clostridium tetani. The high mortality rate is related to frequent tetanic fits with laryngeal spasm and airway obstruction. Numerous anticonvulsants are in use, with varying efficacy in controlling fits. This case report highlights the use of ketamine as adjunctive therapy in the management of tetanus. CASE REPORT: A 20-year-old woman was admitted with a history of recurrent left ear pain, with bloody, purulent discharge, following a self-inflicted injury. She developed tetanic spasms 24 hours after admission. She had received no immunisations. A tracheostomy was established to relieve airway obstruction, and ketamine was added to the medication when breakthrough seizures were refractory to diazepam. CONCLUSION: Ketamine is of proven safety as an anaesthetic agent, especially in cases in which an anaesthetist is not readily available. Its effectiveness in this case, in combination with diazepam, warrants further evaluation.
O Obanor; H O Osazuwa; J E O Amadasun
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-11-26
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  122     ISSN:  1748-5460     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-27     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1389-91     Citation Subset:  AIM; IM    
Dr Amadasun Ear Care Institute, Westend Hospital, Warri, Nigeria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anticonvulsants / administration & dosage*
Diazepam / administration & dosage*
Disease Progression
Ketamine / administration & dosage*
Otitis Externa / complications
Otitis Media, Suppurative / complications
Seizures / drug therapy
Self-Injurious Behavior / complications
Tetanus / drug therapy*
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Anticonvulsants; 439-14-5/Diazepam; 6740-88-1/Ketamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Securing a nasopharyngeal airway.
Next Document:  Safe, complete resection of epiglottic cysts with phono-ultra-microsurgical technique.