Document Detail

Ketamine does not inhibit interleukin-6 synthesis in hepatic resections requiring a temporary porto-arterial occlusion (Pringle manoeuvre): a controlled, prospective, randomized, double-blinded study.
MedLine Citation:
PMID:  21929671     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Previous studies have shown that interleukin-6 (IL-6) levels correlated with mortality in critically ill patients.
GOAL: To determine the effect of ketamine on IL-6 levels in liver resections patients with a temporary porto-arterial occlusion (Pringle manoeuvre).
MATERIALS AND METHODS: Controlled, prospective, randomized, double-blinded study. One group (n = 21) received ketamine whereas the other group (n = 17) received placebo. IL-6 levels were obtained at baseline, 4, 12, 24 h, 3 and 5 days.
RESULTS: There were no significant differences in IL-6 levels between the groups (basal P = 089, 4 hP = 0.83, 12 h P = 0.39, 24 h, P = 0.55, 3 days P = 0.80 and 5 days P = 0.45). Both groups had elevated IL-6 levels that became almost undetectable by day 5. There was no major morbidity and no mortality in either group.
CONCLUSIONS:   Ketamine does not seem to have an effect on plasma levels of IL-6. This could be interpreted as a potential finding associated with outcome as we did not encounter any deaths or major complications. Further studies will likely be needed to determine the range of IL-6 levels associated with survival and mortality, and whether it could be a predictor of survival.
Francisco Carlos Bonofiglio; Ernesto P Molmenti; Eduardo de Santibañes
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-07-22
Journal Detail:
Title:  HPB : the official journal of the International Hepato Pancreato Biliary Association     Volume:  13     ISSN:  1477-2574     ISO Abbreviation:  HPB (Oxford)     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-20     Completed Date:  2012-01-13     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  100900921     Medline TA:  HPB (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  706-11     Citation Subset:  IM    
Copyright Information:
© 2011 International Hepato-Pancreato-Biliary Association.
Department of Anaesthesiology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
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MeSH Terms
Anesthetics, Dissociative / administration & dosage*
Double-Blind Method
Hepatectomy / adverse effects*,  mortality
Interleukin-6 / biosynthesis*,  blood
Ketamine / administration & dosage*
Middle Aged
Prospective Studies
Time Factors
Treatment Outcome
Vascular Surgical Procedures / adverse effects*,  mortality
Reg. No./Substance:
0/Anesthetics, Dissociative; 0/IL6 protein, human; 0/Interleukin-6; 6740-88-1/Ketamine

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