Document Detail

Keratoacanthoma and squamous cell carcinoma of the skin: immunohistochemical localization of involucrin and keratin proteins.
MedLine Citation:
PMID:  2419374     Owner:  NLM     Status:  MEDLINE    
Fifteen keratoacanthomas and fifteen squamous cell carcinomas of the skin were examined by immunoperoxidase methods for involucrin and both 45- and 63-kilodalton keratins. Keratoacanthomas showed a relatively homogeneous staining pattern for involucrin; all cells except basal cells stained with mild to moderate intensity. Squamous cell carcinomas disclosed a highly irregular involucrin staining pattern with marked variation in staining intensity from cell to cell. Staining patterns for keratin proteins did not appear to distinguish between keratoacanthomas and squamous cell carcinomas. The 45-kilodalton keratin pattern showed diffuse staining within both keratoacanthomas and squamous cell carcinomas, and the 63-kilodalton keratin pattern consisted of focal staining, mostly of dyskeratotic cells. These results suggest that involucrin may serve as a diagnostic aid in differentiating between squamous cell carcinomas and keratoacanthomas. In addition, other lesions in the differential diagnosis of keratoacanthoma and squamous cell carcinoma were also examined for involucrin.
B R Smoller; T H Kwan; J W Said; S Banks-Schlegel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  14     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-04-11     Completed Date:  1986-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  226-34     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Squamous Cell / analysis*
Epidermis / analysis
Immunoenzyme Techniques
Keratins / analysis*
Keratoacanthoma / metabolism*
Middle Aged
Neoplasm Proteins / analysis*
Protein Precursors / analysis*
Sebaceous Glands / analysis
Skin Diseases / metabolism
Skin Neoplasms / analysis*
Sweat Glands / analysis
Reg. No./Substance:
0/Neoplasm Proteins; 0/Protein Precursors; 60108-77-2/involucrin; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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