Document Detail


Keratins in health and cancer: more than mere epithelial cell markers.
MedLine Citation:
PMID:  20890307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Keratins are the intermediate filament (IF)-forming proteins of epithelial cells. Since their initial characterization almost 30 years ago, the total number of mammalian keratins has increased to 54, including 28 type I and 26 type II keratins. Keratins are obligate heteropolymers and, similarly to other IFs, they contain a dimeric central α-helical rod domain that is flanked by non-helical head and tail domains. The 10-nm keratin filaments participate in the formation of a proteinaceous structural framework within the cellular cytoplasm and, as such, serve an important role in epithelial cell protection from mechanical and non-mechanical stressors, a property extensively substantiated by the discovery of human keratin mutations predisposing to tissue-specific injury and by studies in keratin knockout and transgenic mice. More recently, keratins have also been recognized as regulators of other cellular properties and functions, including apico-basal polarization, motility, cell size, protein synthesis and membrane traffic and signaling. In cancer, keratins are extensively used as diagnostic tumor markers, as epithelial malignancies largely maintain the specific keratin patterns associated with their respective cells of origin, and, in many occasions, full-length or cleaved keratin expression (or lack there of) in tumors and/or peripheral blood carries prognostic significance for cancer patients. Quite intriguingly, several studies have provided evidence for active keratin involvement in cancer cell invasion and metastasis, as well as in treatment responsiveness, and have set the foundation for further exploration of the role of keratins as multifunctional regulators of epithelial tumorigenesis.
Authors:
V Karantza
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-04
Journal Detail:
Title:  Oncogene     Volume:  30     ISSN:  1476-5594     ISO Abbreviation:  Oncogene     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-13     Completed Date:  2011-02-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  127-38     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA. karantva@umdnj.edu
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / diagnosis*,  metabolism
Animals
Cell Transformation, Neoplastic / metabolism
Cytoplasm / metabolism
Epithelial Cells / metabolism*
Female
Health*
Humans
Intermediate Filaments / chemistry,  metabolism
Keratins / chemistry,  genetics,  metabolism*
Male
Mice
Protein Biosynthesis
Protein Interaction Domains and Motifs
Protein Processing, Post-Translational
Tumor Markers, Biological / chemistry,  genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
R00 CA133181-03/CA/NCI NIH HHS; R00 CA133181-04/CA/NCI NIH HHS; R00CA133181/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; 68238-35-7/Keratins
Comments/Corrections

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