Document Detail


Keratinocytes regain momentum as instigators of cutaneous inflammation.
MedLine Citation:
PMID:  16443394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The primary role of skin is to serve as a protective coat and epidermal keratinocytes are responsible for this barrier function. Besides providing structural support, keratinocytes can initiate inflammatory reactions, thereby enhancing healing of skin that follows barrier perturbation. In complex diseases such as psoriasis, in which both barrier function and cutaneous inflammation are dysregulated, it is unclear whether the primary pathogenic disturbance resides in keratinocytes or in immunocytes, which are commingled in psoriatic plaques. Researchers have turned to animal models of cutaneous inflammation to gain insights into the pathogenesis of psoriasis. A recent report in which the inducible epidermal deletion of Jun proteins in adult mice triggered inflammatory skin lesions and destructive arthritis has shifted momentum towards the keratinocyte as a key instigator of cutaneous inflammation. However, because this transgenic mouse model mimics only some features of psoriasis, further studies are required before the prevailing view of psoriasis as a fundamentally immunocyte-driven disease can be replaced by the notion that keratinocytes are the primary pathogenic cells in psoriasis.
Authors:
Brian J Nickoloff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-01-27
Journal Detail:
Title:  Trends in molecular medicine     Volume:  12     ISSN:  1471-4914     ISO Abbreviation:  Trends Mol Med     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-20     Completed Date:  2006-07-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100966035     Medline TA:  Trends Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  IM    
Affiliation:
Skin Cancer Research Program, Loyola University of Chicago Medical Center, Cardinal Bernardin Cancer Center, 2160 South First Avenue, Building 112, Room 301, Maywood, IL 60153, USA. bnickol@lumc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Humans
Inflammation / metabolism*
Keratinocytes / immunology*
Mice
Mice, Knockout
Mice, Transgenic
Proto-Oncogene Proteins c-jun / genetics,  metabolism
Psoriasis* / immunology,  pathology,  physiopathology
Skin* / cytology,  immunology
Grant Support
ID/Acronym/Agency:
AR 40065/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-jun

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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