Document Detail

Keratinocyte growth factor increases fatty acid mobilization and hepatic triglyceride secretion in rats.
MedLine Citation:
PMID:  7664645     Owner:  NLM     Status:  MEDLINE    
Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family that was originally identified as a keratinocyte mitogen after isolation from a lung fibroblast cell line. In this study, we demonstrate that administration of KGF to mice and rats elevates serum lipid levels. In rats, 1 h after KGF administration, serum triglyceride and FFA levels were increased, with peak values at 2 h (1.9-fold increase). The increase in serum triglyceride levels was sustained for at least 16 h. Serum cholesterol levels were also increased, but the effect was delayed beginning at 4 h, with peak values at 16 h (1.27-fold increase). KGF did not decrease the clearance of triglyceride-rich lipoproteins, but increased hepatic triglyceride secretion. KGF stimulated lipolysis, but not hepatic de novo fatty acid synthesis, and the increased delivery of FFA to the liver plays a crucial role in the KGF-induced hypertriglyceridemia. Neither alpha- nor beta-adrenergic receptor antagonists affected the hypertriglyceridemia induced by KGF, indicating that endogenous catecholamines are not involved in mediating KGF-induced hypertriglyceridemia. These results demonstrate that KGF induces hypertriglyceridemia by increasing hepatic triglyceride secretion, with the fatty acids provided by lipolysis making a major contribution. Thus, KGF could modulate lipid metabolism in vivo.
K Nonogaki; X M Pan; A H Moser; I Staprans; K R Feingold; C Grunfeld
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  136     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-10-12     Completed Date:  1995-10-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4278-84     Citation Subset:  AIM; IM    
Department of Medicine, University of California, San Francisco 94143, USA.
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MeSH Terms
Chylomicrons / metabolism
Fatty Acids / metabolism*
Fibroblast Growth Factor 10
Fibroblast Growth Factor 7
Fibroblast Growth Factors*
Growth Substances / pharmacology*
Lipids / blood
Liver / drug effects*,  secretion
Mice, Inbred C57BL
Rats, Sprague-Dawley
Triglycerides / secretion*
Grant Support
Reg. No./Substance:
0/Chylomicrons; 0/Fatty Acids; 0/Fgf7 protein, mouse; 0/Fgf7 protein, rat; 0/Fibroblast Growth Factor 10; 0/Growth Substances; 0/Lipids; 0/Triglycerides; 126469-10-1/Fibroblast Growth Factor 7; 62031-54-3/Fibroblast Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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