| Keratinocyte growth factor increases fatty acid mobilization and hepatic triglyceride secretion in rats. | |
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MedLine Citation:
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PMID: 7664645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family that was originally identified as a keratinocyte mitogen after isolation from a lung fibroblast cell line. In this study, we demonstrate that administration of KGF to mice and rats elevates serum lipid levels. In rats, 1 h after KGF administration, serum triglyceride and FFA levels were increased, with peak values at 2 h (1.9-fold increase). The increase in serum triglyceride levels was sustained for at least 16 h. Serum cholesterol levels were also increased, but the effect was delayed beginning at 4 h, with peak values at 16 h (1.27-fold increase). KGF did not decrease the clearance of triglyceride-rich lipoproteins, but increased hepatic triglyceride secretion. KGF stimulated lipolysis, but not hepatic de novo fatty acid synthesis, and the increased delivery of FFA to the liver plays a crucial role in the KGF-induced hypertriglyceridemia. Neither alpha- nor beta-adrenergic receptor antagonists affected the hypertriglyceridemia induced by KGF, indicating that endogenous catecholamines are not involved in mediating KGF-induced hypertriglyceridemia. These results demonstrate that KGF induces hypertriglyceridemia by increasing hepatic triglyceride secretion, with the fatty acids provided by lipolysis making a major contribution. Thus, KGF could modulate lipid metabolism in vivo. |
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Authors:
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K Nonogaki; X M Pan; A H Moser; I Staprans; K R Feingold; C Grunfeld |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Endocrinology Volume: 136 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-10-12 Completed Date: 1995-10-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4278-84 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of California, San Francisco 94143, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chylomicrons / metabolism Fatty Acids / metabolism* Fibroblast Growth Factor 10 Fibroblast Growth Factor 7 Fibroblast Growth Factors* Growth Substances / pharmacology* Lipids / blood Lipolysis Liver / drug effects*, secretion Male Mice Mice, Inbred C57BL Rats Rats, Sprague-Dawley Triglycerides / secretion* |
| Grant Support | |
ID/Acronym/Agency:
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DK-40990/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chylomicrons; 0/Fatty Acids; 0/Fgf7 protein, mouse; 0/Fgf7 protein, rat; 0/Fibroblast Growth Factor 10; 0/Growth Substances; 0/Lipids; 0/Triglycerides; 126469-10-1/Fibroblast Growth Factor 7; 62031-54-3/Fibroblast Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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