Document Detail


Keratinocyte apoptosis in epidermal development and disease.
MedLine Citation:
PMID:  16418733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Keratinocyte (KC) apoptosis plays a critical role in regulating epidermal development and restraining carcinogenesis. Apoptosis balances proliferation to maintain epidermal thickness, contributes to stratum corneum formation and may eliminate pre-malignant cells. Apart from the normal developmental program, KC apoptosis can be triggered by UV light and other stimuli. Dysfunctional apoptosis occurs in some skin diseases, such as psoriasis and skin cancer. Here we review the current state of knowledge of KC apoptosis, with particular focus on apoptotic signaling pathways and molecular mechanisms of apoptosis control, and discuss new insights into the complex role of apoptosis in skin carcinogenesis that are emerging from mouse models.
Authors:
Deepak Raj; Douglas E Brash; Douglas Grossman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  126     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-18     Completed Date:  2006-03-07     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  243-57     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Cell Transformation, Neoplastic
Epidermis / cytology,  growth & development*,  metabolism
Keratinocytes / cytology,  physiology*,  radiation effects
Mice
Signal Transduction
Skin Diseases / etiology*
Skin Neoplasms / etiology*
Grant Support
ID/Acronym/Agency:
K08 AR48618/AR/NIAMS NIH HHS; R01 AR050102/AR/NIAMS NIH HHS; R01 AR050102-03/AR/NIAMS NIH HHS; R03 AR048953/AR/NIAMS NIH HHS; R03 AR048953/AR/NIAMS NIH HHS; R03 AR048953-03/AR/NIAMS NIH HHS
Comments/Corrections

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