Document Detail


Keratin 19 demonstration of canal of Hering loss in primary biliary cirrhosis: "minimal change PBC"?
MedLine Citation:
PMID:  22911653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: We suggest that CoH loss demonstrated by K19 immunostaining is an early feature in PBC. Clinical findings in the years following biopsy, including response to ursodeoxycholic acid, show identical changes to patients with biopsy confirmed PBC. We suggest that this "minimal change" feature may support a clinical diagnosis of PBC even in the absence of characteristic, granulomatous, duct destructive lesions.
Authors:
Fahad M Khan; Arathi Rajendra Komarla; Paulo G Mendoza; Henry C Bodenheimer; Neil D Theise
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-04-04     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  700-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Affiliation:
Department of Medicine, Division of Digestive Diseases, Beth Israel Medical Center of Albert Einstein College of Medicine, New York, NY 10003, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bile Ducts, Intrahepatic / pathology*
Biopsy
Female
Humans
Immunohistochemistry
Keratin-19 / analysis*
Liver / pathology
Liver Cirrhosis, Biliary / diagnosis*,  pathology*
Middle Aged
Prospective Studies
Ursodeoxycholic Acid / diagnostic use
Chemical
Reg. No./Substance:
0/Keratin-19; 128-13-2/Ursodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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