Document Detail

Keloid treatment: is there a role for acellular human dermis (Alloderm)?
MedLine Citation:
PMID:  19699700     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Keloid management is faced with high recurrence rates. Keloid fibroblasts lack the normal negative feedback mechanism resulting in an exuberant scar formation. Alloderm doesn't undergo the same proliferative process as keloidal scar dermis. OBJECTIVE: To evaluate Alloderm as a treatment modality for keloids METHODS: A retrospective chart review of six patients with a total of eight large recurrent keloids was performed. Patients were treated with excision of the keloid followed by placement of Alloderm. Each patient was evaluated for recurrence and complications. RESULTS: During follow-up ranging from 1 month to 4(1/2) years there were 0% recurrences. Two out of 8 (25%) had residual induration. one of the two patients with residual induration, required an intralesional injection of kenalog at 6 months post-op. CONCLUSION: Our results from this small study show that with the use of Alloderm after keloid excision, recurrence is low. Further study is warranted.
Nima P Patel; A Lawrence Cervino
Publication Detail:
Type:  Journal Article     Date:  2009-08-22
Journal Detail:
Title:  Journal of plastic, reconstructive & aesthetic surgery : JPRAS     Volume:  63     ISSN:  1878-0539     ISO Abbreviation:  J Plast Reconstr Aesthet Surg     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264239     Medline TA:  J Plast Reconstr Aesthet Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1344-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
Summa Health System/Northeast Ohio Universities College of Medicine, Division of Plastic and Reconstructive Surgery, Akron, Ohio 44304, USA.
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MeSH Terms
Collagen / therapeutic use*
Follow-Up Studies
Glucocorticoids / administration & dosage
Injections, Intralesional
Keloid / therapy*
Middle Aged
Reconstructive Surgical Procedures / methods*
Retrospective Studies
Skin, Artificial
Time Factors
Treatment Outcome
Triamcinolone Acetonide / administration & dosage
Young Adult
Reg. No./Substance:
0/Alloderm; 0/Glucocorticoids; 76-25-5/Triamcinolone Acetonide; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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