Document Detail

Kell alloimmunization in pregnancy: associated with fetal thrombocytopenia?
MedLine Citation:
PMID:  18435678     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Kell haemolytic disease in pregnancies has been suggested to be associated with decreased fetal platelet counts. The aim of this study was to evaluate the incidence and clinical significance of fetal thrombocytopenia in pregnancies complicated by Kell alloimmunization. MATERIALS AND METHODS: In this retrospective cohort study, fetal platelet counts were performed in 42 pregnancies with severe Kell alloimmunization prior to the first intrauterine blood transfusion. Platelet counts from 318 first intrauterine transfusions in RhD alloimmunized pregnancies were used as controls. RESULTS: Fetal thrombocytopenia (platelet count < 150 x 10(9)/l) was found in 4/42 (10%) in the Kell group and in 84/318 (26%) in the RhD group. None of the fetuses in the Kell alloimmunized pregnancies, including 15 with severe hydrops, had a clinically significant thrombocytopenia defined as a platelet count < 50 x 10(9)/l. In the RhD alloimmunized pregnancies, 2/230 (1%) of the non-hydropic fetuses and 7/30 (23%) of the severely hydropic fetuses had a clinically significant thrombocytopenia. CONCLUSION: In contrast to fetuses with severe anaemia and hydrops due to RhD alloimmunization, fetuses with severe anaemia due to Kell alloimmunization are generally not at risk for substantial thrombocytopenia.
E S A van den Akker; F J C M Klumper; A Brand; H H H Kanhai; D Oepkes
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Publication Detail:
Type:  Journal Article     Date:  2008-04-23
Journal Detail:
Title:  Vox sanguinis     Volume:  95     ISSN:  1423-0410     ISO Abbreviation:  Vox Sang.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  England    
Other Details:
Languages:  eng     Pagination:  66-9     Citation Subset:  IM    
Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands.
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MeSH Terms
Blood Group Incompatibility*
Cohort Studies
Fetus / immunology
Kell Blood-Group System / immunology*
Pregnancy Complications, Hematologic / immunology*
Prospective Studies
Rh Isoimmunization / immunology
Thrombocytopenia, Neonatal Alloimmune / etiology*,  immunology
Reg. No./Substance:
0/Kell Blood-Group System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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