Document Detail

Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development.
MedLine Citation:
PMID:  18775506     Owner:  NLM     Status:  MEDLINE    
Gene inactivation studies of mammalian histone and DNA-modifying proteins have demonstrated a role for many such proteins in embryonic development. Post-implantation embryonic lethality implies a role for epigenetic factors in differentiation and in development of specific lineages or tissues. However a handful of chromatin-modifying enzymes have been found to be required in pre- or peri-implantation embryos. This is significant as implantation is the time when inner cell mass cells of the blastocyst exit pluripotency and begin to commit to form the various lineages that will eventually form the adult animal. These observations indicate a critical role for chromatin-modifying proteins in the earliest lineage decisions of mammalian development, and/or in the formation of the first embryonic cell types. Recent work has shown that the two major class I histone deacetylase-containing co-repressor complexes, the NuRD and Sin3 complexes, are both required at peri-implantation stages of mouse development, demonstrating the importance of histone deacetylation in cell fate decisions. Over the past 10 years both genetic and biochemical studies have revealed surprisingly divergent roles for these two co-repressors in mammalian cells. In this review we will summarise the evidence that the two major class I histone deacetylase complexes in mammalian cells, the NuRD and Sin3 complexes, play important roles in distinct aspects of embryonic development.
Patrick McDonel; Ita Costello; Brian Hendrich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-08-14
Journal Detail:
Title:  The international journal of biochemistry & cell biology     Volume:  41     ISSN:  1357-2725     ISO Abbreviation:  Int. J. Biochem. Cell Biol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-04-02     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9508482     Medline TA:  Int J Biochem Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  108-16     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation
Cell Proliferation
Embryonic Development / genetics
Gene Expression Regulation, Developmental*
Histone Deacetylases / genetics,  metabolism*
Mammals / embryology
Mi-2 Nucleosome Remodeling and Deacetylase Complex
Models, Biological
Sin3 Histone Deacetylase and Corepressor Complex
Stem Cells / cytology,  metabolism
Transcription, Genetic
Grant Support
081816//Wellcome Trust; G0300723//Medical Research Council; G0800784//Medical Research Council; //Wellcome Trust
Reg. No./Substance:
EC Deacetylases; EC Nucleosome Remodeling and Deacetylase Complex; EC Histone Deacetylase and Corepressor Complex

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