Document Detail

Keeping an eye on retinoic acid signaling during eye development.
MedLine Citation:
PMID:  18831967     Owner:  NLM     Status:  MEDLINE    
Retinoic acid is a metabolic derivative of vitamin A that plays an essential function in cell-cell signaling by serving as a ligand for nuclear receptors that directly regulate gene expression. The final step in the conversion of retinol to retinoic acid is carried out by three retinaldehyde dehydrogenases encoded by Raldh1 (Aldh1a1), Raldh2 (Aldh1a2), and Raldh3 (Aldh1a3). Mouse Raldh gene knockout studies have been instrumental in understanding the mechanism of retinoic acid action during eye development. Retinoic acid signaling in the developing eye is particularly complex as all three Raldh genes contribute to retinoic acid synthesis in non-overlapping locations. During optic cup formation Raldh2 is first expressed transiently in perioptic mesenchyme, then later Raldh1 and Raldh3 expression begins in the dorsal and ventral retina, respectively, and these sources of retinoic acid are maintained in the fetus. Retinoic acid is not required for dorsoventral patterning of the retina as originally thought, but it is required for morphogenetic movements that form the optic cup, ventral retina, cornea, and eyelids. These findings will help guide future studies designed to identify retinoic acid target genes during eye organogenesis.
Gregg Duester
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-09-11
Journal Detail:
Title:  Chemico-biological interactions     Volume:  178     ISSN:  1872-7786     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-02-27     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  178-81     Citation Subset:  IM    
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MeSH Terms
Aldehyde Dehydrogenase / genetics,  metabolism
Eye / embryology*
Gene Knockdown Techniques
Mice, Transgenic
Signal Transduction*
Tretinoin / metabolism*
Grant Support
EY013969/EY/NEI NIH HHS; R01 EY013969/EY/NEI NIH HHS; R01 EY013969-06/EY/NEI NIH HHS
Reg. No./Substance:
5688UTC01R/Tretinoin; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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