Document Detail

Kawasaki disease.
MedLine Citation:
PMID:  11480756     Owner:  NLM     Status:  MEDLINE    
Kawasaki disease is an acute self-limited vasculitis of infancy and early hildhood that is now the leading cause of acquired heart disease in children in the United States and Japan. An infectious cause is suspected, although the etiology remains unknown. Children typically are seen with the acute onset of fever followed by signs of mucosal inflammation and vasodilatation that evolve over the first week of the illness. Laboratory tests reveal a marked systemic inflammatory response. If untreated, 1 in 4 children will develop permanent damage to the coronary arteries. Intravenous gamma globulin in conjunction with aspirin is effective in reducing the inflammation and preventing coronary artery abnormalities if administered within the first 10 days of illness. This poses a difficult situation for the pediatric care provider who must distinguish Kawasaki disease from other rash/fever syndromes in a timely manner so that appropriate therapy can be initiated.
J C Burns
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in pediatrics     Volume:  48     ISSN:  0065-3101     ISO Abbreviation:  Adv Pediatr     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-01     Completed Date:  2001-12-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370436     Medline TA:  Adv Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-77     Citation Subset:  IM    
Department of Pediatrics, UCSD School of Medicine, La Jolla, Calif, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Aspirin / therapeutic use
Child, Preschool
Coronary Disease / etiology
Immunoglobulins, Intravenous
Infant, Newborn
Mucocutaneous Lymph Node Syndrome* / diagnosis,  drug therapy,  etiology
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Immunoglobulins, Intravenous; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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