Document Detail


Kawasaki disease in Thai infants compared with older children.
MedLine Citation:
PMID:  15005968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infants with Kawasaki disease (KD) are at increased risk of having coronary artery abnormalities (CAA). The purpose of this study was to evaluate the clinical features of KD in infants and compare these with findings in older children to determine the risk factors for CAA in infants. All children with KD admitted to a tertiary care hospital between January 1993 and April 2003 were studied retrospectively. Of a total of 51 patients included in the study, 22 (43%) were <1 year of age (mean 8 months, range 2-12 months). All had classical clinical manifestations such as fever, skin rash and mucositis; extremity change occurred in 95%, conjunctivitis in 81% and cervical lymphadenopathy in 27%. Infants had significantly more non-classical symptoms, e.g. diarrhoea (68%), than older children (38%) (p=0.04). The mean number of days before intravenous immunoglobulin (IVIG) treatment was given to infants was 2 days later than in older children. The predictors of CAA in infants were resistance to IVIG treatment (p=0.02) and long duration of fever (p=0.009). Compared with older children, the less typical presentations and delay in diagnosis and treatment in infants might be important factors in CAA in KD.
Authors:
Rekwan Sittiwangkul; Yupada Pongprot; Wanathorn Thongsongkrit; Suchaya Silvilairat; Charlie Phornphutkul
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  24     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-09     Completed Date:  2004-06-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. rsittiwa@med.cmu.ac.th
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Child, Preschool
Coronary Artery Disease / etiology
Diarrhea / epidemiology,  etiology
Female
Humans
Immunoglobulins, Intravenous / administration & dosage
Incidence
Infant
Male
Mucocutaneous Lymph Node Syndrome / blood,  complications,  epidemiology*
Prevalence
Retrospective Studies
Risk Factors
Thailand / epidemiology
Chemical
Reg. No./Substance:
0/Immunoglobulins, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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