Document Detail


Kawasaki disease, Epstein-Barr virus and coronary artery aneurysms.
MedLine Citation:
PMID:  9155700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To establish whether infection with Epstein-Barr virus (EBV) contributed to the development of coronary artery lesions in a six year old child with an aneurysm and stenoses of the coronary arteries and suspected Kawasaki disease. METHODS: Postmortem paraffin wax sections of the coronary artery and myocardium were examined by in situ hybridisation for expression of EBER-1 (EBV-encoded RNA-1). Positive controls consisted of an EBV positive case of Hodgkin disease and a case of posttransplantation lymphoma. RESULTS: No EBER-1 positive cells were identified in either myocardium or walls of the coronary artery. CONCLUSIONS: Although EBV has been implicated in the aetiology of Kawasaki disease and development of coronary artery lesions, this process was not confirmed in this patient. It is likely that an unusual immunological reaction to a primary EBV infection with suspected deregulation of T helper cell activity leads to severe coronary artery damage in early childhood.
Authors:
G A Culora; I E Moore
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  50     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-05-29     Completed Date:  1997-05-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  161-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Histopathology, Southampton University Hospital NHS Trust.
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MeSH Terms
Descriptor/Qualifier:
Child
Coronary Aneurysm / complications,  pathology,  virology*
Coronary Disease / complications,  pathology,  virology
Heart / virology
Herpesvirus 4, Human / isolation & purification*
Humans
In Situ Hybridization
Male
Mucocutaneous Lymph Node Syndrome / complications,  pathology,  virology*
Comments/Corrections

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