| Kawasaki disease. | |
| | |
MedLine Citation:
|
PMID: 17484817 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
Kawasaki disease is an acute vasculitis of childhood, complicated by coronary artery aneurysms in up to 25% of affected children. High-dose intravenous immunoglobulin (IVIG) administered in the acute phase of Kawasaki disease leads to a fivefold reduction in the prevalence of coronary aneurysms. When fever persists, a second IVIG infusion should be administered. Rescue therapies for IVIG-resistant Kawasaki disease include pulsed-dose methylprednisolone or other steroid regimens, as well as infliximab, a tumor necrosis factor-alpha antagonist. Aspirin is used initially in an anti-inflammatory dosage, then at a low dosage until approximately 6 weeks after illness onset. Patients with coronary aneurysms require chronic antithrombotic therapy. For small aneurysms, aspirin alone is sufficient. For larger aneurysms, agents added to aspirin include clopidogrel and, for giant aneurysms, warfarin or low molecular weight heparin. Long-term management is tailored to the degree of coronary artery involvement. Evidence-based data to guide indications for transcatheter and surgical intervention are limited. |
| | |
Authors:
|
Jane W Newburger; David R Fulton |
Related Documents
:
|
8227387 - Application of intracoronary ultrasonography in the study of coronary artery pathophysi... 22100927 - Computed tomographic angiography in tetralogy of fallot. 10086577 - Reminiscences of vasilii i. kolesov. 8609337 - The atropine factor in pharmacologic stress echocardiography. echo persantine (epic) an... 2486787 - Traumatic aneurysms and arteriovenous fistula of the upper limb. 19932267 - Arterial switch for transposition of the great vessels and taussig-bing anomaly after s... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current treatment options in cardiovascular medicine Volume: 9 ISSN: 1092-8464 ISO Abbreviation: Curr Treat Options Cardiovasc Med Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-05-08 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9815942 Medline TA: Curr Treat Options Cardiovasc Med Country: United States |
Other Details:
|
Languages: eng Pagination: 148-58 Citation Subset: - |
Affiliation:
|
Department of Cardiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA. jane.newburger@cardio.chboston.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Complications of aortic atherosclerosis: atheroemboli and thromboemboli.
Next Document: Critical limb ischemia.