| Kaurenoic Acid from Pulp of Annona cherimolia in regard to Annonaceae-induced Parkinsonism. | |
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MedLine Citation:
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PMID: 21520310 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Guadeloupean Parkinsonism has been linked epidemiologically to the consumption of Annonaceae fruits. These were proposed to be etiological agents for sporadic atypical Parkinsonism worldwide, because of their content of neurotoxins such as isoquinolinic alkaloids and Annonaceous acetogenins. The pulp of Annona cherimolia Mill. from Spain was screened for these toxic molecules using Matrix-Assisted Laser Desorption Ionisation - Time of Flight mass spectrometry (MALDI-TOF MS) and it was found not to be a source of exposure. However, kaurenoic acid, a diterpene considered to be cytotoxic, was detected in high amounts (66 mg/fresh fruit). Treatment of rat embryonic striatal primary cultures, up to a high concentration (50 µm), did not cause neuronal death nor astrogliosis, suggesting that this molecule is not at risk of implication in human neurodegenerative diseases. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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R Guillopé; M Escobar-Khondiker; V Guérineau; O Laprévote; G U Höglinger; P Champy |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-25 |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: - ISSN: 1099-1573 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Laboratoire de Pharmacognosie, CNRS UMR 8076 BioCIS, Faculté de Pharmacie, Université Paris-Sud 11, 92296, Châtenay-Malabry, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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