Document Detail


Kasumigamide, an antialgal peptide from the cyanobacterium Microcystis aeruginosa.
MedLine Citation:
PMID:  10987919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kasumigamide (1), a novel antialgal tetrapeptide containing an N-terminal alpha-hydroxy acid, was isolated from the freshwater cyanobacterium Microcystis aeruginosa (NIES-87). Its structure was elucidated by two-dimensional (1)H-(1)H and (1)H-(13)C NMR correlation experiments and confirmed by mass spectral and amino acid analyses. The absolute stereochemistry of 1 was determined by chemical studies. This peptide showed an antialgal activity against the green alga Chlamydomonas neglecta (NIES-439).
Authors:
K Ishida; M Murakami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  65     ISSN:  0022-3263     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-11-07     Completed Date:  2000-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5898-900     Citation Subset:  IM    
Affiliation:
Laboratory of Marine Biochemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
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MeSH Terms
Descriptor/Qualifier:
Algae, Green / drug effects*
Amino Acids / analysis
Chromatography, High Pressure Liquid
Magnetic Resonance Spectroscopy
Microcystis / chemistry*
Oligopeptides / chemistry*,  isolation & purification,  toxicity
Pesticides / chemical synthesis*,  pharmacology
Spectrometry, Mass, Fast Atom Bombardment
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Oligopeptides; 0/Pesticides; 0/kasumigamide

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