Document Detail


Kasabach merritt syndrome: management with interferon.
MedLine Citation:
PMID:  21063527     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Kasabach Merritt Syndrome (KMS) is a rare, locally aggressive, vascular tumor. The objectives of treatment of KMS are to prevent bleeding from consumptive coagulopathy and induce vascular tumor regression. A 14-month old female child was brought with a reddish lesion on the left scapular area noticed at birth, which suddenly increased in size since 3 days. Hemogram revealed anemia severe thrombocytopenia, prolongation of bleeding, clotting time and increased fibrin degradable products, suggestive of KMS. Coagulopathy was managed by transfusing fresh frozen plasma and platelets. Oral prednisolone up to 5mg/kg/day for four weeks yielded no effect on thrombocytopenia or regression of tumor size. Embolization of feeding artery was attempted but not feasible. We used Interferon -alpha- 2b (IFN α 2b), in a dosage of 3million IU/m(2) /day subcutaneously. Within a month the platelet count increased and the vascular tumor started regressing. This case signifies the importance of step wise management of KMS.
Authors:
Sandhya Acharya; Kalyani Pillai; Abel Francis; S Criton; V K Parvathi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of dermatology     Volume:  55     ISSN:  1998-3611     ISO Abbreviation:  Indian J Dermatol     Publication Date:    2010 Jul-Sep
Date Detail:
Created Date:  2010-11-10     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0370750     Medline TA:  Indian J Dermatol     Country:  India    
Other Details:
Languages:  eng     Pagination:  281-3     Citation Subset:  -    
Affiliation:
Department of Dermatology, Amala Institute of Medical Sciences,(AIMS), Thrissur, Kerala, India.
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