Document Detail

Kappa-opioid receptor antisense oligonucleotide injected into rat hippocampus causes hypertension.
MedLine Citation:
PMID:  10448926     Owner:  NLM     Status:  MEDLINE    
Bi-hippocampal microinjection treatment (1 microg per side, twice a day for 5 days) with an antisense phosphorothioate oligodeoxynucleotide antisense oligodeoxynucleotide to the rat kappa-opioid receptor, caused hypertension in normotensive Wistar Kyoto (WKY) rats and increased the blood pressure of spontaneously hypertensive rats (SHR). Systolic blood pressure in WKY rats increased from 121+/-4 to 153+/-6 mm Hg, and in SHR systolic blood pressure increased from 153+/-4 to 183+/-5 mm Hg. Similar results were observed with mean blood pressure, however, there were no changes in heart rate. No significant responses were seen with either vehicle or missense injections. Radioligand binding studies indicated that there was a significant decrease in apparent kappa-opioid receptor density due to antisense oligodeoxynucleotide treatment. The results are in accord with our earlier suggestions that the kappa-opioid system in the hippocampus may have a role in the neural control of blood pressure.
R C Wright; M M McConnaughey; T A Phan; A J Ingenito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  377     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-08     Completed Date:  1999-09-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
Department of Pharmacology, Brody 6S-10, ECU School of Medicine, East Carolina University, Greenville, NC 27858, USA.
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MeSH Terms
Binding, Competitive
Blood Pressure / drug effects
Hippocampus / drug effects*,  metabolism
Hypertension / chemically induced*,  physiopathology
Oligonucleotides, Antisense / pharmacology*
Radioligand Assay
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Opioid, kappa / antagonists & inhibitors*,  genetics,  metabolism
Reg. No./Substance:
0/Oligonucleotides, Antisense; 0/Receptors, Opioid, kappa

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