Document Detail

Kappa-opioid receptor antagonism improves recovery from myocardial stunning in chronically instrumented dogs.
MedLine Citation:
PMID:  17000788     Owner:  NLM     Status:  MEDLINE    
We tested the hypothesis that the selective kappa-opioid receptor antagonist nor-binaltorphimine (nor-BNI) improves recovery from myocardial stunning. Ten dogs were chronically instrumented for measurement of heart rate, left atrial, aortic and left ventricular pressure (LVP), and the maximum rate of LVP increase (LV dP/dt(max)) and decrease (LV dP/dt(max)), coronary blood flow velocity and myocardial wall-thickening fraction. Regional myocardial blood flow was determined with fluorescent microspheres. Catecholamine plasma levels were measured by high-performance liquid chromatography, and beta-endorphin and dynorphin plasma levels by radioimmunoassay. An occluder around the left anterior descending artery (LAD) allowed induction of a reversible LAD-ischemia. Animals underwent two experiments in a randomized crossover fashion on separate days: (a) 10 min LAD-occlusion (control experiment), (b) second ischemic episode 24 h after nor-BNI (2.5 mg/kg IV) (intervention). Dogs receiving nor-BNI showed an increase in wall-thickening fraction, LV dP/dt(max) and LV dP/dt(min) before ischemia and during the whole reperfusion (P < 0.05 versus control experiment). After nor-BNI pretreatment, dynorphin levels increased after induction of ischemia to a peak level of 15.1 +/- 3.6 pg/mL (P < 0.05 versus control experiment). The increase in plasma beta-endorphin during ischemia and early reperfusion was attenuated after nor-BNI. Compared with the control experiment, nor-BNI left global hemodynamics, regional myocardial blood flow, and catecholamine levels unchanged. In conclusion, nor-BNI improves recovery from myocardial stunning after regional myocardial ischemia in chronically instrumented dogs.
Maike A Grosse Hartlage; Marc M Theisen; Nelson P Monteiro de Oliveira; Hugo Van Aken; Manfred Fobker; Thomas P Weber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  103     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-26     Completed Date:  2006-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  822-32     Citation Subset:  AIM; IM    
Department of Anaesthesiology and Intensive Care, University Hospital Münster, Münster, Germany.
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MeSH Terms
Blood Pressure / drug effects
Coronary Circulation / drug effects
Dynorphins / blood
Epinephrine / blood
Heart Rate / drug effects
Myocardial Stunning / drug therapy*,  physiopathology
Naltrexone / analogs & derivatives*,  pharmacology
Narcotic Antagonists / pharmacology*
Norepinephrine / blood
Receptors, Opioid, kappa / antagonists & inhibitors*
Ventricular Function, Left / drug effects
beta-Endorphin / blood
Reg. No./Substance:
0/Narcotic Antagonists; 0/Receptors, Opioid, kappa; 105618-26-6/norbinaltorphimine; 16590-41-3/Naltrexone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 60617-12-1/beta-Endorphin; 74913-18-1/Dynorphins

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