| Kaposi's sarcoma: an update. | |
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MedLine Citation:
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PMID: 15334644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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While there have been many important advances in the study of Kaposi's sarcoma (KS), it remains both a challenge and an enigma in many ways. Kaposi's original description of "multiple idiopathic hemorrhagic sarcoma[s]" in patients who died within 2-3 years resembles KS in AIDS more than classic KS in elderly men of Italian, Jewish, or Mediterranean lineage, in whom the disease is usually benign. KS had been evident in about one-third of those with early AIDS, often as its presenting sign, a pattern markedly reduced in recent times since the introduction of highly active anti-retroviral therapy (HAART). The most important advance has been the convincing etiologic linkage of KS with human herpesvirus 8 (HHV-8), which is necessary but not sufficient. It has a low prevalence in the general population of the USA and UK, with an intermediate rate in Italy and Greece, and a high one in Uganda. KS risk may be significantly lower in AIDS patients with a history of anti-herpes therapy. Many aspects of HHV-8, including its transmission pattern and different genospecies, are being scrutinized. The diagnosis of KS may be difficult. One should be aware of KS clinical variants, including telangiectatic, eccymotic, and keloidal KS. One must consider a number of other disorders, including bacillary angiomatosis. HHV-8 DNA sequences in dermatofibromas and other tumors should probably not be viewed as representing a marker for KS. Therapeutic options vary for KS. Intralesional and low-dose outpatient intravenous vinblastine may be valuable, as immunosuppression with KS is not a good idea if it can be avoided. Anti-herpes virus therapy may have potential for wide use, especially in preventing the development of KS in at risk populations, such as HHV-8 seropositive individuals undergoing transplantation surgery. |
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Authors:
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Robert A Schwartz |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of surgical oncology Volume: 87 ISSN: 0022-4790 ISO Abbreviation: J Surg Oncol Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-30 Completed Date: 2004-09-21 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0222643 Medline TA: J Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 146-51 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Dermatology, New Jersey Medical School, Newark, New Jersey 07103, USA. roschwar@umdnj.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications* Anti-HIV Agents / therapeutic use Anti-Retroviral Agents / therapeutic use Antiretroviral Therapy, Highly Active* DNA, Viral Diagnosis, Differential HIV Seropositivity Herpesvirus 8, Human / genetics, pathogenicity Humans Sarcoma, Kaposi* / drug therapy, epidemiology, pathology, prevention & control Skin Neoplasms / epidemiology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Anti-Retroviral Agents; 0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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