Document Detail


Kaposi's sarcoma and non-Hodgkin's lymphoma incidence trends in AIDS Clinical Trial Group study participants.
MedLine Citation:
PMID:  10430216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Combination therapy with protease inhibitors and nucleoside analogues dramatically suppresses plasma HIV-1 RNA and delays progression to AIDS, but the impact on HIV-associated malignancy remains to be established. We therefore examined incidence trends of Kaposi's sarcoma and non-Hodgkin's lymphoma in patients with advanced HIV infection in nine AIDS Clinical Trial Group studies of antiviral therapies for HIV and cytomegalovirus infections. Among a total of 6587 patients enrolled between November 1987 and February 1997, there were 280 cases of Kaposi's sarcoma and 68 cases of non-Hodgkin's lymphoma. Incidence rates per 100 person-years of both malignancies declined in concert with decreases in mortality, but the decreases in Kaposi's sarcoma were more profound and consistent than the decreases in non-Hodgkin's lymphoma. These data suggest that current therapies have ameliorated the incidence of Kaposi's sarcoma, but may not have had an equal effect on non-Hodgkin's lymphoma.
Authors:
C S Rabkin; M A Testa; J Huang; J H Von Roenn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  21 Suppl 1     ISSN:  1525-4135     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-08-24     Completed Date:  1999-08-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S31-3     Citation Subset:  IM; X    
Affiliation:
Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / complications,  drug therapy,  epidemiology*
Anti-HIV Agents / adverse effects*
Antiviral Agents / therapeutic use
Clinical Trials as Topic
Cytomegalovirus Retinitis / complications,  drug therapy
Foscarnet / therapeutic use
Ganciclovir / therapeutic use
HIV Infections / complications*,  drug therapy
Humans
Incidence
Indinavir / therapeutic use
Lymphoma, AIDS-Related / complications,  epidemiology*
Lymphoma, Non-Hodgkin / complications,  epidemiology*
Retrospective Studies
Sarcoma, Kaposi / complications,  epidemiology*
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Antiviral Agents; 150378-17-9/Indinavir; 4428-95-9/Foscarnet; 82410-32-0/Ganciclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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