Document Detail

Kaposi's sarcoma in an elderly man with Wegener's granulomatosis treated with cyclophosphamide and corticosteroids.
MedLine Citation:
PMID:  3365087     Owner:  NLM     Status:  MEDLINE    
The association of Kaposi's sarcoma with malignant lymphoreticular diseases and immunosuppressive therapy is well documented. This report describes an elderly man who presented with fulminant Wegener's granulomatosis that responded to treatment with cyclophosphamide and corticosteroids. Rapidly progressing cutaneous Kaposi's sarcoma developed ten weeks after the start of immunosuppressive therapy yet regressed on discontinuation of the corticosteroid therapy, despite continuation of cyclophosphamide therapy. To our knowledge, this is the first reported case of Kaposi's sarcoma occurring in association with Wegener's granulomatosis. The literature on Kaposi's sarcoma in immunosuppressed patients is reviewed.
S B Erban; R K Sokas
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  148     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-05-27     Completed Date:  1988-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1201-3     Citation Subset:  AIM; IM    
Section of General Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104.
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MeSH Terms
Cyclophosphamide / therapeutic use*
Methylprednisolone / adverse effects
Prednisone / adverse effects*
Sarcoma, Kaposi / chemically induced*
Skin Neoplasms / chemically induced*
Wegener Granulomatosis / drug therapy*
Reg. No./Substance:
50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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