| Kaolin-induced congenital hydrocephalus in utero in fetal lambs and rhesus monkeys. | |
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MedLine Citation:
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PMID: 6537789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A model of congenital hydrocephalus in utero in fetal lambs and rhesus monkeys has been produced by the intracisternal injection of kaolin. Initial attempts to produce hydrocephalus using silicone oil were unrewarding. Hydrocephalus had developed by 2 weeks post-injection and could be followed by ultrasonography. The pathological findings were similar to those reported using kaolin in other species. Ventriculoamniotic shunting, when successful, was capable of partially reversing the deleterious effects of hydrocephalus. The major drawback of the present model is that hydrocephalus is produced during the second rather than the first trimester of pregnancy. However, kaolin produces mainly an obstructive hydrocephalus without other associated brain or systemic anomalies. |
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Authors:
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M S Edwards; M R Harrison; M Halks-Miller; D K Nakayama; M S Berger; P L Glick; D H Chinn |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurosurgery Volume: 60 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-01-26 Completed Date: 1984-01-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 115-22 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Female Fetal Diseases / chemically induced, diagnosis, physiopathology* Hydrocephalus / chemically induced*, diagnosis, pathology, physiopathology* Kaolin* Macaca mulatta Pregnancy Sheep Silicones Ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Silicones; 1332-58-7/Kaolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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