| Kallmann's syndrome: is it always for life? | |
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MedLine Citation:
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PMID: 10468907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Kallmann's syndrome (KS) is defined by the association of olfactory deficit with irreversible, congenital gonadotrophin deficiency (IHH). We present evidence for the existence of a variant form of KS, in which endogenous gonadotrophin secretion recovers spontaneously in later life. DESIGN: Longitudinal clinical study. PATIENTS: Five men with anosmia or severe hyposmia, who originally presented in their late teens or early twenties as a result of severe pubertal delay and were thus presumed to have KS. RESULTS: Spontaneous onset of endogenous gonadotrophin secretion, evidenced by progressive normalization of testicular volume and of serum testosterone concentration, occurred in these men over a period of years following the initial diagnosis. CONCLUSIONS: This variant form of Kallman's syndrome is not well recognized and may well be under-diagnosed. Once full virilization has been induced, males with congenital gonadotrophin deficiency whose testes have significantly increased in size should be reassessed, off androgen replacement therapy, to identify those who no longer require treatment. |
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Authors:
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R Quinton; H K Cheow; D J Tymms; P M Bouloux; F C Wu; H S Jacobs |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical endocrinology Volume: 50 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-09-30 Completed Date: 1999-09-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 481-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, University College London, UK. r.quinton@ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Follow-Up Studies Gonadotropins, Pituitary / blood, secretion* Humans Kallmann Syndrome / physiopathology* Male Remission, Spontaneous Testis / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Gonadotropins, Pituitary |
| Comments/Corrections | |
Comment In:
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Clin Endocrinol (Oxf). 1999 Dec;51(6):817-8
[PMID:
10619991
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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