Document Detail


KSRP and MiR-145 Are Negative Regulators of Lipolysis in White Adipose Tissue.
MedLine Citation:
PMID:  24732799     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
White adipose tissue (WAT) releases fatty acids from stored triacylglycerol (TAG) for energy source. Here, we report that targeted deletion of KH-type splicing regulatory protein (KSRP), an RNA-binding protein that regulates gene expression at multiple levels, enhances lipolysis in epididymal WAT (eWAT) due to up-regulation of genes promoting lipolytic activity. Expression of miR-145 is decreased due to impaired pri-miR-145 processing in Ksrp(-/-) eWAT. We show that miR-145 directly targets and represses Foxo1 and Cgi58, activators of lipolytic activity, and forced expression of miR-145 attenuates lipolysis. This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through post-transcriptional regulation of miR-145 expression.
Authors:
Yi-Yu Lin; Chu-Fang Chou; Matteo Giovarelli; Paola Briata; Roberto Gherzi; Ching-Yi Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-14
Journal Detail:
Title:  Molecular and cellular biology     Volume:  -     ISSN:  1098-5549     ISO Abbreviation:  Mol. Cell. Biol.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109087     Medline TA:  Mol Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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