| KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. | |
| | |
MedLine Citation:
|
PMID: 20364091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The linkage of Kaposi sarcoma (KS) to infection by a novel human herpesvirus (Kaposi sarcoma-associated herpesvirus [KSHV]) is one of the great successes of contemporary biomedical research and was achieved by using advanced genomic technologies in a manner informed by a nuanced understanding of epidemiology and clinical investigation. Ongoing efforts to understand the molecular mechanisms by which KSHV infection predisposes to KS continue to be powerfully influenced by insights emanating from the clinic. Here, recent developments in KS pathogenesis are reviewed, with particular emphasis on clinical, pathologic, and molecular observations that highlight the many differences between this process and tumorigenesis by other oncogenic viruses. |
| | |
Authors:
|
Don Ganem |
Publication Detail:
|
Type: Journal Article; Review Date: 2010-04-01 |
Journal Detail:
|
Title: The Journal of clinical investigation Volume: 120 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-05 Completed Date: 2010-04-21 Revised Date: 2013-05-29 |
Medline Journal Info:
|
Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
|
Languages: eng Pagination: 939-49 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine and Microbiology, University of California, 513 Parnassus Ave., San Francisco, CA 91413, USA. ganem@cgl.ucsf.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Herpesvirus 8, Human
/
genetics,
pathogenicity*,
physiology Humans Sarcoma, Kaposi / etiology*, virology Viral Tropism Virus Latency Virus Replication |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established...
Next Document: How we are born.