Document Detail

KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine.
MedLine Citation:
PMID:  20364091     Owner:  NLM     Status:  MEDLINE    
The linkage of Kaposi sarcoma (KS) to infection by a novel human herpesvirus (Kaposi sarcoma-associated herpesvirus [KSHV]) is one of the great successes of contemporary biomedical research and was achieved by using advanced genomic technologies in a manner informed by a nuanced understanding of epidemiology and clinical investigation. Ongoing efforts to understand the molecular mechanisms by which KSHV infection predisposes to KS continue to be powerfully influenced by insights emanating from the clinic. Here, recent developments in KS pathogenesis are reviewed, with particular emphasis on clinical, pathologic, and molecular observations that highlight the many differences between this process and tumorigenesis by other oncogenic viruses.
Don Ganem
Publication Detail:
Type:  Journal Article; Review     Date:  2010-04-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  120     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-04-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  939-49     Citation Subset:  AIM; IM    
Department of Medicine and Microbiology, University of California, 513 Parnassus Ave., San Francisco, CA 91413, USA.
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MeSH Terms
Herpesvirus 8, Human / genetics,  pathogenicity*,  physiology
Sarcoma, Kaposi / etiology*,  virology
Viral Tropism
Virus Latency
Virus Replication

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