Document Detail

KL-6: marker for pulmonary involvement in Langerhans cell histiocytosis in infants.
MedLine Citation:
PMID:  15342985     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to investigate serum KL-6 levels in an infant with Langerhans cell histiocytosis (LCH) and pulmonary involvement. The histologic diagnosis of LCH was established by skin biopsy. Imaging of the chest confirmed marked interstitial shadowing throughout both lung fields. Acutely, serum KL-6 was elevated to 9,400 U/mL. Following induction chemotherapy, clinical manifestations of LCH improved and the levels of serum KL-6 returned to within normal limits. During the maintenance therapy phase, there was a resurgence of the LCH, but without involvement of the lungs, and the levels of KL-6 remained normal. The authors conclude that KL-6 may be a useful marker for pulmonary involvement in infants with LCH.
Tadashi Matsubayashi; Yasuhiro Miwa; Isamu Saito; Rie Matsubayashi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  26     ISSN:  1077-4114     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-02     Completed Date:  2004-11-01     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  584-6     Citation Subset:  IM    
Division of Pediatrics, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
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MeSH Terms
Antigens / blood*
Antigens, Neoplasm
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Biological Markers / blood*
Glycoproteins / blood*
Histiocytosis, Langerhans-Cell / blood*,  diagnosis*,  drug therapy
Infant, Newborn
Lung / pathology*
Tomography, X-Ray Computed
Reg. No./Substance:
0/Antigens; 0/Antigens, Neoplasm; 0/Biological Markers; 0/Glycoproteins; 0/MUC1 protein, human; 0/Mucin-1; 0/Mucins

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