| KL-6 as an indicator for lymphocytic interstitial pneumonia (LIP) in a human T-lymphotrophic virus type 1 (HTLV-1) carrier. | |
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MedLine Citation:
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PMID: 12224007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 59-year-old woman was admitted to our hospital complaining of a productive cough, dyspnea on effort, and low-grade fever. Although chest X-rays showed no marked abnormalities, her level of serum KL-6 was extremely high. We therefore suspected the presence of interstitial pneumonia. High-resolution computed tomography (CT) scan revealed infiltrative shadows in S6 of the right lung, and her serum was positive for antihuman T-lymphotropic virus type 1 (HTLV-1) antibodies. From the clinical symptoms, radiographic findings, and histological findings, the diagnosis was probable lymphocytic interstitial pneumonia (LIP). After high-dose corticosteroid therapy, the level of serum KL-6 decreased rapidly. We conclude that KL-6 is a convenient and reliable marker for evaluating the activity of pulmonary manifestations in HTLV-1 carriers and that it is especially useful in monitoring the effectiveness of treatments. |
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Authors:
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N Ishikawa; Y Awaya; H Maeda; M Miyazaki; K Fujitaka; M Yamasaki; K Kondo; T Oguri; T Isobe; N Kohno |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2002-07-31 |
Journal Detail:
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Title: Annals of hematology Volume: 81 ISSN: 0939-5555 ISO Abbreviation: Ann. Hematol. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-09-11 Completed Date: 2002-12-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: Germany |
Other Details:
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Languages: eng Pagination: 474-7 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Hiroshima University Faculty of Medicine, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Antigens Antigens, Neoplasm Biological Markers / blood Carrier State Female Glycoproteins HTLV-I Antibodies / blood HTLV-I Infections / diagnosis*, immunology Humans Lung / pathology Lung Diseases, Interstitial / complications, diagnosis*, drug therapy, pathology Middle Aged Mucin-1 Mucins Tomography, X-Ray Computed Trachea / pathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Antigens; 0/Antigens, Neoplasm; 0/Biological Markers; 0/Glycoproteins; 0/HTLV-I Antibodies; 0/MUC1 protein, human; 0/Mucin-1; 0/Mucins |
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