| KIT and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma. | |
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MedLine Citation:
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PMID: 20537211 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Small cell carcinoma has the worst prognosis of all laryngeal neoplasms. In order to further characterise this tumour, with a view to development of new therapeutic approaches, we report the results of KIT gene and platelet-derived growth factor receptor α gene expression analysis, for two extremely rare cases of primary small cell carcinoma of the larynx. METHOD: Case reports, including immunohistochemical study, and review of the literature. RESULTS: We present two patients with laryngeal small cell carcinoma, who died from tumour metastasis to the lungs and brain despite aggressive treatment. Immunohistochemical studies revealed positive reactions for KIT gene expression and platelet-derived growth factor α gene expression in patient one, and for KIT gene expression in patient two. Molecular genetic analysis, using polymerase chain reaction direct sequencing, identified no mutations of the KIT or platelet-derived growth factor receptor α genes. CONCLUSION: Although further investigation is necessary regarding KIT gene expression and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma, the reported results suggest that these genes may be significant in the development of molecular targeted therapy. |
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Authors:
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T Kanazawa; M Nokubi; K Takizawa; S Matsuzawa; A Shinnabe; H Mineta; Y Iino |
Publication Detail:
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Type: Journal Article Date: 2010-06-11 |
Journal Detail:
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Title: The Journal of laryngology and otology Volume: 124 ISSN: 1748-5460 ISO Abbreviation: J Laryngol Otol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706896 Medline TA: J Laryngol Otol Country: England |
Other Details:
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Languages: eng Pagination: 1340-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Saitama City, Saitama, Japan. kanatake@omiya.jichi.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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