| KIT gene mutation analysis in solid tumours: biology, clincial applications and trends in diagnostic reporting. | |
| | |
MedLine Citation:
|
PMID: 23277171 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
SUMMARY: Gain-of-function mutations involving c-kit protein, a cell-surface transmembrane receptor for stem cell factor, have been identified as a key oncogenic driver in a variety of solid tumours. Coupled with the development of tyrosine kinase inhibitors such as imatinib, c-kit has emerged as a viable drug target in what seems to be a validated therapeutic concept. This review will focus on gastrointestinal stromal tumours and melanomas, two types of solid tumours most closely associated with KIT gene mutations. The biology of KIT mutations in both conditions, as well as the value of KIT mutation testing in predicting disease and treatment outcomes are discussed. Since initial response to imatinib is largely influenced by mutation status, genotyping these tumours serves to facilitate personalised oncology. We also summarise our experience with diagnostic reporting of KIT mutation analysis over a period of 3 years, and briefly survey future developments in treatment, which indeed look very promising. |
| | |
Authors:
|
Clifton Ming Tay; Chee Wee Ong; Victor Kwan Min Lee; Brendan Pang |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pathology Volume: 45 ISSN: 1465-3931 ISO Abbreviation: Pathology Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0175411 Medline TA: Pathology Country: England |
Other Details:
|
Languages: eng Pagination: 127-37 Citation Subset: IM |
Affiliation:
|
*Yong Loo Lin School of Medicine, National University of Singapore †Department of Pathology, National University Health System, Singapore ‡Cancer Science Institute, National University of Singapore, Singapore. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tumours associated with BAP1 mutations.
Next Document: TRAIL and osteoprotegerin (OPG) expression in bladder urothelial carcinoma: correlation with clinic...