| KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection. | |
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MedLine Citation:
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PMID: 22022261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on the T cell response in human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection. |
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Authors:
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Nafisa-Katrin Seich Al Basatena; Aidan Macnamara; Alison M Vine; Chloe L Thio; Jacquie Astemborski; Koichiro Usuku; Mitsuhiro Osame; Gregory D Kirk; Sharyne M Donfield; James J Goedert; Charles R M Bangham; Mary Carrington; Salim I Khakoo; Becca Asquith |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2011-10-13 |
Journal Detail:
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Title: PLoS pathogens Volume: 7 ISSN: 1553-7374 ISO Abbreviation: PLoS Pathog. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: 2012-04-16 Revised Date: 2012-04-24 |
Medline Journal Info:
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Nlm Unique ID: 101238921 Medline TA: PLoS Pathog Country: United States |
Other Details:
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Languages: eng Pagination: e1002270 Citation Subset: IM |
Affiliation:
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Imperial College, London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Genes, MHC Class I HTLV-I Infections / genetics, immunology*, virology Hepacivirus / immunology, physiology Hepatitis C, Chronic / genetics, immunology*, virology Histocompatibility Antigens Class I / immunology* Human T-lymphotropic virus 1 / immunology, physiology Humans Killer Cells, Natural / immunology, metabolism, virology Male Receptors, KIR / immunology Receptors, KIR2DL2 / genetics*, metabolism* T-Lymphocytes / immunology Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 HD41224/HD/NICHD NIH HHS; 261200800001E//PHS HHS; R01 DA004334/DA/NIDA NIH HHS; R01-DA-04334/DA/NIDA NIH HHS; R01-DA-12568/DA/NIDA NIH HHS; R01-DA-16078/DA/NIDA NIH HHS; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Histocompatibility Antigens Class I; 0/KIR2DL2 protein, human; 0/Receptors, KIR; 0/Receptors, KIR2DL2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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